MRI Technology That Non-Invasively Locates, Quantifies Specific Cells In The Body

�Magnetic resonance imaging (MRI) isn't hardly for capturing detailed images of the body's frame.



Thanks to novel tomography reagents and technology developed by Carnegie Mellon University scientist Eric Ahrens, MRI can be used to visualize - with "exquisite" specificity - cell populations of interestingness in the living body. The ability to non-invasively locate and track cells, such as immune cells, will greatly aid the study and treatment of cancer, lighting, and autoimmune diseases, as well as provide a tool for advancing clinical translation of the emerging field of cellular regenerative medicine, by tracking stem cells for example.



Ahrens presented his enquiry on this new approach, called fluorocarbon labeling, Thursday, Aug. 21 at the 236th national meeting of the American Chemical Society in Philadelphia.



"With our engineering we seat image specific cells in real-time with exquisite selectivity, which allows us to track their location and movement and to count the apparent number of cells present. We then use conventional MRI to obtain a high-resolution image that places the labeled cells in their anatomic context," aforesaid Ahrens, an associate prof of biological sciences at the Mellon College of Science.



The ability to cartroad the movement and eventual location of specific immune cells is critical for understanding the cells' role in disease and curative mechanisms, and for developing effective cell-based therapeutics. Other MRI methods for visualizing cells use metal-based line agents, which can construct it hard to clear identify labeled cells in the body, according to Ahrens.



"The large background signal from mobile water and intrinsic tissue contrast differences can often make it challenging to unambiguously key regions containing these metal-ion labeled cells throughout the body, which is the current state of the art," Ahrens said.



Ahrens's new approach - fluorocarbon labeling - solves this problem by producing images that clearly show the labelled cells at their exact location in the body. Ahrens first labels the cells of interest with a perfluoropolyether (PFPE) nanoemulsion, which is a colloidal suspension of tiny fluorocarbon droplets. Then, he introduces the labelled cells into an brute subject and tracks the cells in vivo using 19F MRI.



While conventional MRI detects the nuclear magnetised resonance signal from protons contained in the wandering water in tissue, 19F MRI detects the signal from the nucleus of the fluorine atom. Fluorine is non normally submit in the body at sufficient concentrations to discover, so when Ahrens labels cells with PFPE, he can discover this fluorine 'tracer' with MRI later on the cells are transplanted into the body. The Ahrens' team has lately used the PFPE engineering to mark and lead dendritic cells and T cells in a mouse model of type I diabetes, a disease in which immune cells infiltrate the pancreas, attacking and damaging the body's own cells.



"Right now we're using our engineering to image key cell types mired in autoimmune diseases like type I diabetes, just our cellular MRI agents also canful be adapted to label other cell types, including cells from bone substance and stem cells. A key semipermanent application of our engineering science is to label and monitor cell-based therapeutics in humans," Ahrens said.



Recent advances in cell-based therapeutics research have focussed on training immune cells to neutralize diseases including cancer and diabetes and on directional stem cells to revitalize damaged tissues. Non-invasively visualizing these therapeutic cells in patients after transfer lav be a vexing problem, according to Ahrens, and any approaching that keister speed up the testing of these treatments will be exceedingly useful.



"Ideally we would label therapeutic cells with our cellular MRI agents in front they are implanted into a patient. In this way, we could employment MRI to visualize the movement of the therapeutic cells in the affected role to monitor whether they migrate to and remain in the desired tissues," explained Ahrens.




Ahrens's current process is funded by the National Institutes of Health.



About Carnegie Mellon:



Carnegie Mellon is a private inquiry university with a classifiable mix of programs in engineering, calculator science, robotics, business, public policy, fine arts and the liberal arts. More than 10,000 undergraduate and graduate students receive an education characterized by its focus on creating and implementing solutions for real problems, interdisciplinary collaboration, and innovation. A small student-to-faculty ratio provides an opportunity for close interaction between students and professors. While technology is pervasive on its 144-acre Pittsburgh campus, Carnegie Mellon is too distinctive among leading research universities for the world-renowned programs in its College of Fine Arts. A global university, Carnegie Mellon has campuses in Silicon Valley, Calif., and Qatar, and programs in Asia, Australia and Europe. For more, ascertain http://www.cmu.edu/.



Source: Jocelyn Duffy

Carnegie Mellon University




More info

• Despite expanding diagnostic imaging, Canada lags behind other developed countries
• Face transplant ‘double success’
• Fruit juice ‘could affect drugs’
• Hospital death rates unveiled for first-time comparison
• Mexican peppers posing salmonella risk still being sold

Download Katatonia

Artist: Katatonia: mp3 download    Genre(s):  Rock Metal: Doom Metal: Death,Black Metal Metal: Gothic Other Gothic     Discography:      Live Consternation    Year: 2007    Tracks: 1      Discouraged Ones    Year: 2007    Tracks: 13      The Great Cold Distance    Year: 2006    Tracks: 12      My Twin    Year: 2006    Tracks: 4      Deliberation (Single)    Year: 2006    Tracks: 2      Viva Emptiness    Year: 2005    Tracks: 13      The Black Sessions (Disk 2)    Year: 2005    Tracks: 15      The Black Sessions (Disk 1)    Year: 2005    Tracks: 15      Dance of December Souls    Year: 2005    Tracks: 8      Brave Yester Days    Year: 2004    Tracks: 23      Live In Vicenza    Year: 2003    Tracks: 17      Live in Madrid    Year: 2003    Tracks: 16      Live at KGB Barcelona    Year: 2003    Tracks: 16      Sounds of Decay    Year: 2002    Tracks: 3      Tonight's Music    Year: 2001    Tracks: 3      Tonight's Decision    Year: 2001    Tracks: 11      Teargas    Year: 2001    Tracks: 3      Live in Paris    Year: 2001    Tracks: 13      Last Fair Deal Gone Down    Year: 2001    Tracks: 11      Jhva Elohim Meth... The Revival    Year: 2000    Tracks: 5      Saw You Drown    Year: 1998    Tracks: 4      Brave Murder Day    Year: 1997    Tracks: 10      Primordial - Katatonia (Split With Primordial)    Year: 1996    Tracks: 1      For Funerals to Come    Year: 1994    Tracks: 4 Katatonia ar a Swedish death/doom-metal trio light-emitting crystal rectifier by guitar player Blackheim. The group's mo album, Braw Murder Day, featured Opeth vocaliser Mikael Akerfeldt and was their low to be released internationally; Century Media paired it with an out of mark EP, For Funerals to Come. They consistently released albums throughout the 1890s. Their roster includes Dance of December Souls (1993), Gay Murder Day (1997), Discouraged One (1998), and Tonight's Decision (1999). Net Fair Deal Gone Down appeared in bounce 2001.

Stonewall presents.. The Campest Clips EVER!

Campest Clips Ever DVD!

Ladies, Gentlemen & Undecided� strap on your heels and pour yourself a Cosmo as for the first time on DVD, Stonewall Hotel presents the Campest Clips Ever!

From the home of Dame Edna Everage, The Minogues & Priscilla Queen of the Desert, bring together celebrity presenters Maxi Shield & Candy Box as they take you on a hilarious ride through some of the campest moments in music video history. It�s just like 80s weekend on MTV, only camper!!!

There are dress ups to be had, tragic and cliche remarks to be made, and plenty of fashion do and don'ts to be witnessed! Maxi and Candy perform skits, give hilarious introductions to segments and allow the men amoung us to have a bloody good perve! There's covers, groups, history and entertainers, simply to name a few of the chapter titles!

Whether it�s George Michael�s petite hot knickers, Cyndi Lauper�s outrageous style or Frankie�s leather-clad boys that got banned around the world, there are more pleasurably flamboyant moments (and clich�s) than an Elton John birthday party.

Loaded with plentitude of attitude, bitchiness, dresses & wigs, The Campest Clips Ever is unrivalled big party in pinko, sequined box!

Featured Videos

Culture Club - Do You Really Want To Hurt Me

Adam Rickett - I Breathe Again

Bearforce 1 - Bearforce 1

Wham - Wake Me Up Before You Go-Go

Gloria Gaynor - I Will Survive

Frankie Goes To Hollywood - Relax

Hairspray - You Can't Stop The Beat

The Source Ft. Candi Staton - You Got The Love

Melissa Tkautz - Glamorous Life

Alyson Moyet & Dawn French - Whispering Your Name

Grace Jones - Pull Up To The Bumper

Aqua - Barbie Girl

Vengaboys - We Like To Party

Cascada - Everytime We Touch

Nicki French - Total Eclipse Of The Heart

Slinkee Minx - Summer Rain

Divided - Easy Lover

Groove Generation Ft. Leo Sayer - You Make Me Feel Like Dancing

B-52's - Love Shack

Bronski Beat - Small Town Boy

Divinyls - I Touch Myself

Yazoo - Only You

Bananarama - Move In My Direction (Moto Blanco)

Dvd Extras Featured Videos

Outtakes

Follow The Adventure Preview

More information

• Riley Lee and Colin Wilson
• Celebs in the TMZZZZZzzzz
• Carl Palmer
• Shift
• Bow Wow Reunites With Dupri In Studio

Reese Witherspoon - Witherspoon Phillippe Finalise All Divorce Details

Actress REESE WITHERSPOON's marriage to RYAN PHILLIPPE is officially over - their divorce was finalised on Thursday (12Jun08).

The couple ended its seven-year marriage when they separated in 2006 and the union was dissolved on 5 October (07), but the pair has only now fully resolved all financial and custodial issues.

Court documents filed in Los Angeles on Thursday reads: "(The court finds) the parties have settled all their remaining issues in these proceedings."

Witherspoon and Phillippe have since moved on to new relationships. The Legally Blonde star is currently dating Jake Gyllenhaal, while Phillippe recently went public with his romance with Abbie Cornish.

Witherspoon and Phillippe have two children - daughter Ava, eight, and son Deacon, four.

See Also

• Art Pepper and Carl Perkins and Ben Tucker and Chu
• S. Balachander
• WALL STREET JOURNAL BEST-SELLERS
• Pete Doherty: ‘Babyshambles need to stop arsing about’

Tiesto - Elements of Life Remixed

Fresh from a breathtaking Australian tour, Tiesto has released Elements of Life Remixed, out now through Central Station Records. Featuring 12 stunning remixes, Tiesto�s Elements Of Life remix album gives the original album tracks a whole new lease on life with remixes by Cosmic Gate, Richard Durand, Dirty South, Fonzerelli and many more. As a bonus, the package also contains �No More Heroes� featuring the Blue Man Group, who�ve appeared at many of the Elements Of Life world tour shows.
After selling out venues nation wide on his recent Australian tour, and with a spot guest programming Rage to coincide with the release, Tiesto mania shows no sign of letting up! This release is a guaranteed must-have tour memento.
TRACKLISTING
1. Ten Seconds Before Sunrise (First State Remix) (7:43)
2. Everything (featuring JES) (Cosmic Gate Remix) (7:52)
3. Do You Feel Me (featuring Julie Thompson) (Roger Martinez Remix) (5:08)
4. Carpe Noctum (Fire Element Mix) (5:48)
5. Driving To Heaven (Mat Zo Remix) (7:10)
6. Sweet Things (featuring Charlotte Martin) (Tom Cloud Remix) (6:25)
7. Bright Morningstar (Andy Duguid Remix) (7:36)
8. Break My Fall (featuring BT) (Richard Durand Remix) (5:23)
9. In The Dark (featuring Christian Burns) (Dirty South Remix) (5:49)
10. Dance4Life (featuring Maxi Jazz) (Fonzerelli Remix) (6:17)
11. Elements Of Life (Alex Kunnari Remix) (6:33)
Bonustrack. No More Heroes (featuring Blue Man Group) (6:15)

Filmmaker Ari Gold Makes ‘Frogger: The Movie’

One of the funniest and oddest features at this year’s Sundance Film Festival was a resolutely offbeat film about an air-drumming dreamer called The Adventures of Power, co-starring Entourage’s Adrian Grenier and directed by one Ari Gold. Yes — his name is Ari Gold, and the Entourage folks evidently “borrowed” his name for the show’s loathsome-lovable agent. (Gold and Grenier also play in the band the Honey Brothers together.) And although Power was Gold’s first feature film, many veteran Sundance viewers were familiar with him — three of his shorts had previously screened at the festival. One of them, 1996’s Frog Crossing, co-directed by Jamie Babbit (But I’m a Cheerleader), is another look at a crazy dreamer: A hyper enviro-conscious man stands by an empty stretch of highway warning passing motorists to brake for frogs. Meanwhile, a woman drives along the same highway, happily munching on her snacks, oblivious to the world around her. Needless to say, it’s only a matter of time before these two lonely souls connect. —Bilge Ebiri

Pete Wentz - Wentz Defends Simpsons Secret Pregnancy

PETE WENTZ has defended his decision to keep his wife ASHLEE SIMPSON's pregnancy a secret from the media - insisting he wanted to "protect her and the baby".

The couple was dogged by baby rumours for weeks, but refused to confirm the news until Wednesday (28May08) - after Simpson had passed the first trimester of her pregnancy.

And the Fall Out Boy guitarist felt it was only right to keep the news quiet until his wife was given a full bill of health from doctors.

He tells MTV.com, "Every woman, no matter who they are or what they do for a living, has the right to wait at least three months before sharing this very personal news. We wanted to wait until after the first trimester before confirming anything, just like any other couple.

"Being a boy I have no idea how to respond to such things and my first instinct was to protect her and the baby.

"It's insane that you can't let happy news brew in Hollywood. This wasn't about press or anything. It was about the health of the baby and trying to find a way to be happy with what should be the most happy time of our lives in the middle of a press blitz.

"I apologize to anyone who felt misinformed but the truth is, the person and growing baby is who I felt most loyal to protect and defend."

The pair wed in Encino, California earlier this month (17May08).

See Also

• Dj Samantha Ronson - Lohan Denies Confirming Lindsays Lesbian Romance
• Keira Knightley - Fascinating Fact 5337
• Mauss
• Baby on the way for Wonder Years star