�Magnetic resonance imaging (MRI) isn't hardly for capturing detailed images of the body's frame.
Thanks to novel tomography reagents and technology developed by Carnegie Mellon University scientist Eric Ahrens, MRI can be used to visualize - with "exquisite" specificity - cell populations of interestingness in the living body. The ability to non-invasively locate and track cells, such as immune cells, will greatly aid the study and treatment of cancer, lighting, and autoimmune diseases, as well as provide a tool for advancing clinical translation of the emerging field of cellular regenerative medicine, by tracking stem cells for example.
Ahrens presented his enquiry on this new approach, called fluorocarbon labeling, Thursday, Aug. 21 at the 236th national meeting of the American Chemical Society in Philadelphia.
"With our engineering we seat image specific cells in real-time with exquisite selectivity, which allows us to track their location and movement and to count the apparent number of cells present. We then use conventional MRI to obtain a high-resolution image that places the labeled cells in their anatomic context," aforesaid Ahrens, an associate prof of biological sciences at the Mellon College of Science.
The ability to cartroad the movement and eventual location of specific immune cells is critical for understanding the cells' role in disease and curative mechanisms, and for developing effective cell-based therapeutics. Other MRI methods for visualizing cells use metal-based line agents, which can construct it hard to clear identify labeled cells in the body, according to Ahrens.
"The large background signal from mobile water and intrinsic tissue contrast differences can often make it challenging to unambiguously key regions containing these metal-ion labeled cells throughout the body, which is the current state of the art," Ahrens said.
Ahrens's new approach - fluorocarbon labeling - solves this problem by producing images that clearly show the labelled cells at their exact location in the body. Ahrens first labels the cells of interest with a perfluoropolyether (PFPE) nanoemulsion, which is a colloidal suspension of tiny fluorocarbon droplets. Then, he introduces the labelled cells into an brute subject and tracks the cells in vivo using 19F MRI.
While conventional MRI detects the nuclear magnetised resonance signal from protons contained in the wandering water in tissue, 19F MRI detects the signal from the nucleus of the fluorine atom. Fluorine is non normally submit in the body at sufficient concentrations to discover, so when Ahrens labels cells with PFPE, he can discover this fluorine 'tracer' with MRI later on the cells are transplanted into the body. The Ahrens' team has lately used the PFPE engineering to mark and lead dendritic cells and T cells in a mouse model of type I diabetes, a disease in which immune cells infiltrate the pancreas, attacking and damaging the body's own cells.
"Right now we're using our engineering to image key cell types mired in autoimmune diseases like type I diabetes, just our cellular MRI agents also canful be adapted to label other cell types, including cells from bone substance and stem cells. A key semipermanent application of our engineering science is to label and monitor cell-based therapeutics in humans," Ahrens said.
Recent advances in cell-based therapeutics research have focussed on training immune cells to neutralize diseases including cancer and diabetes and on directional stem cells to revitalize damaged tissues. Non-invasively visualizing these therapeutic cells in patients after transfer lav be a vexing problem, according to Ahrens, and any approaching that keister speed up the testing of these treatments will be exceedingly useful.
"Ideally we would label therapeutic cells with our cellular MRI agents in front they are implanted into a patient. In this way, we could employment MRI to visualize the movement of the therapeutic cells in the affected role to monitor whether they migrate to and remain in the desired tissues," explained Ahrens.
Ahrens's current process is funded by the National Institutes of Health.
About Carnegie Mellon:
Carnegie Mellon is a private inquiry university with a classifiable mix of programs in engineering, calculator science, robotics, business, public policy, fine arts and the liberal arts. More than 10,000 undergraduate and graduate students receive an education characterized by its focus on creating and implementing solutions for real problems, interdisciplinary collaboration, and innovation. A small student-to-faculty ratio provides an opportunity for close interaction between students and professors. While technology is pervasive on its 144-acre Pittsburgh campus, Carnegie Mellon is too distinctive among leading research universities for the world-renowned programs in its College of Fine Arts. A global university, Carnegie Mellon has campuses in Silicon Valley, Calif., and Qatar, and programs in Asia, Australia and Europe. For more, ascertain http://www.cmu.edu/.
Source: Jocelyn Duffy
Carnegie Mellon University
More info
Thursday, 4 September 2008
Friday, 15 August 2008
Download Katatonia
 Artist: Katatonia: mp3 download Genre(s): Rock Metal: Doom Metal: Death,Black Metal Metal: Gothic Other Gothic Discography:  Live Consternation Year: 2007 Tracks: 1  Discouraged Ones Year: 2007 Tracks: 13  The Great Cold Distance Year: 2006 Tracks: 12  My Twin Year: 2006 Tracks: 4  Deliberation (Single) Year: 2006 Tracks: 2  Viva Emptiness Year: 2005 Tracks: 13  The Black Sessions (Disk 2) Year: 2005 Tracks: 15  The Black Sessions (Disk 1) Year: 2005 Tracks: 15  Dance of December Souls Year: 2005 Tracks: 8  Brave Yester Days Year: 2004 Tracks: 23  Live In Vicenza Year: 2003 Tracks: 17  Live in Madrid Year: 2003 Tracks: 16  Live at KGB Barcelona Year: 2003 Tracks: 16  Sounds of Decay Year: 2002 Tracks: 3  Tonight's Music Year: 2001 Tracks: 3  Tonight's Decision Year: 2001 Tracks: 11  Teargas Year: 2001 Tracks: 3  Live in Paris Year: 2001 Tracks: 13  Last Fair Deal Gone Down Year: 2001 Tracks: 11  Jhva Elohim Meth... The Revival Year: 2000 Tracks: 5  Saw You Drown Year: 1998 Tracks: 4  Brave Murder Day Year: 1997 Tracks: 10  Primordial - Katatonia (Split With Primordial) Year: 1996 Tracks: 1  For Funerals to Come Year: 1994 Tracks: 4 Katatonia ar a Swedish death/doom-metal trio light-emitting crystal rectifier by guitar player Blackheim. The group's mo album, Braw Murder Day, featured Opeth vocaliser Mikael Akerfeldt and was their low to be released internationally; Century Media paired it with an out of mark EP, For Funerals to Come. They consistently released albums throughout the 1890s. Their roster includes Dance of December Souls (1993), Gay Murder Day (1997), Discouraged One (1998), and Tonight's Decision (1999). Net Fair Deal Gone Down appeared in bounce 2001. |
Thursday, 7 August 2008
Stonewall presents.. The Campest Clips EVER!
Campest Clips Ever DVD!
More information
Ladies, Gentlemen & Undecided� strap on your heels and pour yourself a Cosmo as for the first time on DVD, Stonewall Hotel presents the Campest Clips Ever!
From the home of Dame Edna Everage, The Minogues & Priscilla Queen of the Desert, bring together celebrity presenters Maxi Shield & Candy Box as they take you on a hilarious ride through some of the campest moments in music video history. It�s just like 80s weekend on MTV, only camper!!!
There are dress ups to be had, tragic and cliche remarks to be made, and plenty of fashion do and don'ts to be witnessed! Maxi and Candy perform skits, give hilarious introductions to segments and allow the men amoung us to have a bloody good perve! There's covers, groups, history and entertainers, simply to name a few of the chapter titles!
Whether it�s George Michael�s petite hot knickers, Cyndi Lauper�s outrageous style or Frankie�s leather-clad boys that got banned around the world, there are more pleasurably flamboyant moments (and clich�s) than an Elton John birthday party.
Loaded with plentitude of attitude, bitchiness, dresses & wigs, The Campest Clips Ever is unrivalled big party in pinko, sequined box!
Featured Videos
Culture Club - Do You Really Want To Hurt Me
Adam Rickett - I Breathe Again
Bearforce 1 - Bearforce 1
Wham - Wake Me Up Before You Go-Go
Gloria Gaynor - I Will Survive
Frankie Goes To Hollywood - Relax
Hairspray - You Can't Stop The Beat
The Source Ft. Candi Staton - You Got The Love
Melissa Tkautz - Glamorous Life
Alyson Moyet & Dawn French - Whispering Your Name
Grace Jones - Pull Up To The Bumper
Aqua - Barbie Girl
Vengaboys - We Like To Party
Cascada - Everytime We Touch
Nicki French - Total Eclipse Of The Heart
Slinkee Minx - Summer Rain
Divided - Easy Lover
Groove Generation Ft. Leo Sayer - You Make Me Feel Like Dancing
B-52's - Love Shack
Bronski Beat - Small Town Boy
Divinyls - I Touch Myself
Yazoo - Only You
Bananarama - Move In My Direction (Moto Blanco)
Dvd Extras Featured Videos
Outtakes
Follow The Adventure Preview
More information
Friday, 27 June 2008
Reese Witherspoon - Witherspoon Phillippe Finalise All Divorce Details
Actress REESE WITHERSPOON's marriage to RYAN PHILLIPPE is officially over - their divorce was finalised on Thursday (12Jun08).
The couple ended its seven-year marriage when they separated in 2006 and the union was dissolved on 5 October (07), but the pair has only now fully resolved all financial and custodial issues.
Court documents filed in Los Angeles on Thursday reads: "(The court finds) the parties have settled all their remaining issues in these proceedings."
Witherspoon and Phillippe have since moved on to new relationships. The Legally Blonde star is currently dating Jake Gyllenhaal, while Phillippe recently went public with his romance with Abbie Cornish.
Witherspoon and Phillippe have two children - daughter Ava, eight, and son Deacon, four.
See Also
Sunday, 22 June 2008
Tiesto - Elements of Life Remixed
Fresh from a breathtaking Australian tour, Tiesto has released Elements of Life Remixed, out now through Central Station Records. Featuring 12 stunning remixes, Tiesto�s Elements Of Life remix album gives the original album tracks a whole new lease on life with remixes by Cosmic Gate, Richard Durand, Dirty South, Fonzerelli and many more. As a bonus, the package also contains �No More Heroes� featuring the Blue Man Group, who�ve appeared at many of the Elements Of Life world tour shows.
After selling out venues nation wide on his recent Australian tour, and with a spot guest programming Rage to coincide with the release, Tiesto mania shows no sign of letting up! This release is a guaranteed must-have tour memento.
TRACKLISTING
1. Ten Seconds Before Sunrise (First State Remix) (7:43)
2. Everything (featuring JES) (Cosmic Gate Remix) (7:52)
3. Do You Feel Me (featuring Julie Thompson) (Roger Martinez Remix) (5:08)
4. Carpe Noctum (Fire Element Mix) (5:48)
5. Driving To Heaven (Mat Zo Remix) (7:10)
6. Sweet Things (featuring Charlotte Martin) (Tom Cloud Remix) (6:25)
7. Bright Morningstar (Andy Duguid Remix) (7:36)
8. Break My Fall (featuring BT) (Richard Durand Remix) (5:23)
9. In The Dark (featuring Christian Burns) (Dirty South Remix) (5:49)
10. Dance4Life (featuring Maxi Jazz) (Fonzerelli Remix) (6:17)
11. Elements Of Life (Alex Kunnari Remix) (6:33)
Bonustrack. No More Heroes (featuring Blue Man Group) (6:15)
After selling out venues nation wide on his recent Australian tour, and with a spot guest programming Rage to coincide with the release, Tiesto mania shows no sign of letting up! This release is a guaranteed must-have tour memento.
TRACKLISTING
1. Ten Seconds Before Sunrise (First State Remix) (7:43)
2. Everything (featuring JES) (Cosmic Gate Remix) (7:52)
3. Do You Feel Me (featuring Julie Thompson) (Roger Martinez Remix) (5:08)
4. Carpe Noctum (Fire Element Mix) (5:48)
5. Driving To Heaven (Mat Zo Remix) (7:10)
6. Sweet Things (featuring Charlotte Martin) (Tom Cloud Remix) (6:25)
7. Bright Morningstar (Andy Duguid Remix) (7:36)
8. Break My Fall (featuring BT) (Richard Durand Remix) (5:23)
9. In The Dark (featuring Christian Burns) (Dirty South Remix) (5:49)
10. Dance4Life (featuring Maxi Jazz) (Fonzerelli Remix) (6:17)
11. Elements Of Life (Alex Kunnari Remix) (6:33)
Bonustrack. No More Heroes (featuring Blue Man Group) (6:15)
Saturday, 14 June 2008
Filmmaker Ari Gold Makes ‘Frogger: The Movie’
One of the funniest and oddest features at this year’s Sundance Film Festival was a resolutely offbeat film about an air-drumming dreamer called The Adventures of Power, co-starring Entourage’s Adrian Grenier and directed by one Ari Gold. Yes — his name is Ari Gold, and the Entourage folks evidently “borrowed” his name for the show’s loathsome-lovable agent. (Gold and Grenier also play in the band the Honey Brothers together.) And although Power was Gold’s first feature film, many veteran Sundance viewers were familiar with him — three of his shorts had previously screened at the festival. One of them, 1996’s Frog Crossing, co-directed by Jamie Babbit (But I’m a Cheerleader), is another look at a crazy dreamer: A hyper enviro-conscious man stands by an empty stretch of highway warning passing motorists to brake for frogs. Meanwhile, a woman drives along the same highway, happily munching on her snacks, oblivious to the world around her. Needless to say, it’s only a matter of time before these two lonely souls connect. —Bilge Ebiri
Monday, 9 June 2008
Pete Wentz - Wentz Defends Simpsons Secret Pregnancy
PETE WENTZ has defended his decision to keep his wife ASHLEE SIMPSON's pregnancy a secret from the media - insisting he wanted to "protect her and the baby".
The couple was dogged by baby rumours for weeks, but refused to confirm the news until Wednesday (28May08) - after Simpson had passed the first trimester of her pregnancy.
And the Fall Out Boy guitarist felt it was only right to keep the news quiet until his wife was given a full bill of health from doctors.
He tells MTV.com, "Every woman, no matter who they are or what they do for a living, has the right to wait at least three months before sharing this very personal news. We wanted to wait until after the first trimester before confirming anything, just like any other couple.
"Being a boy I have no idea how to respond to such things and my first instinct was to protect her and the baby.
"It's insane that you can't let happy news brew in Hollywood. This wasn't about press or anything. It was about the health of the baby and trying to find a way to be happy with what should be the most happy time of our lives in the middle of a press blitz.
"I apologize to anyone who felt misinformed but the truth is, the person and growing baby is who I felt most loyal to protect and defend."
The pair wed in Encino, California earlier this month (17May08).
See Also
Kylie tells Britney to "reach out" for help
Pop singer Kylie Minogue has advised troubled star Britney Spears to "reach out" for whatever help she needs.
Speaking to The Sun, Australian singer Minogue said: "Who knows what is going on in her life? Britney isn't that young anymore. I think she will still come back but it's like she's taken an extended holiday."
She continued: "Whatever help she needs, she should reach out and get it. I wish someone would write a manual about fame because it's not easy."
The singer also said: "I'm always loath to say that because there are a lot more difficulties out there that people deal with every day - but when fame is handed to you, it is unique."
She added: "It's not to the same extreme, but I can remember having a mini-meltdown myself - and unless you've got good people around to support you, you've got a problem."
Speaking to The Sun, Australian singer Minogue said: "Who knows what is going on in her life? Britney isn't that young anymore. I think she will still come back but it's like she's taken an extended holiday."
She continued: "Whatever help she needs, she should reach out and get it. I wish someone would write a manual about fame because it's not easy."
The singer also said: "I'm always loath to say that because there are a lot more difficulties out there that people deal with every day - but when fame is handed to you, it is unique."
She added: "It's not to the same extreme, but I can remember having a mini-meltdown myself - and unless you've got good people around to support you, you've got a problem."
Star returns in Prison Break twist
It is reported that actress Sarah Wayne Callies will return as Dr Sara Tancredi for the fourth series of 'Prison Break'.
Fans had thought that Callies' character was killed during season three because of a scene with a Polaroid of her head in a box.
Speaking to E! about Callies' return, the show's executive producer Matt Olmstead said: "It wasn't because of the fans that we did that, but it was the combination of the fans' reactions on the boards and emails, and people we, the writers, know personally would ask about it. And that led us all to have conversations internally, about the fact that there were a lot of people out there asking, "Is she really dead?"
He continued: "We knew internally that when we didn't get Sarah Wayne Callies to come back in season three and be there to portray her character's death, as soon as it was written and filmed and we saw it on screen, we knew that it was actually a way you could describe how this wasn't Sarah's head in the box, basically. But at that point, we were going forward with other stories, so we kind of put that on the back burner."
He added: "But throughout that time we watched how people externally were really talking about what we thought might be the case, internally: The question of, "Is Sara Tancredi really dead?" So throughout season three we were mindful of references we'd make to and who took credit for killing her and all kinds of stuff regarding her death."
Fans had thought that Callies' character was killed during season three because of a scene with a Polaroid of her head in a box.
Speaking to E! about Callies' return, the show's executive producer Matt Olmstead said: "It wasn't because of the fans that we did that, but it was the combination of the fans' reactions on the boards and emails, and people we, the writers, know personally would ask about it. And that led us all to have conversations internally, about the fact that there were a lot of people out there asking, "Is she really dead?"
He continued: "We knew internally that when we didn't get Sarah Wayne Callies to come back in season three and be there to portray her character's death, as soon as it was written and filmed and we saw it on screen, we knew that it was actually a way you could describe how this wasn't Sarah's head in the box, basically. But at that point, we were going forward with other stories, so we kind of put that on the back burner."
He added: "But throughout that time we watched how people externally were really talking about what we thought might be the case, internally: The question of, "Is Sara Tancredi really dead?" So throughout season three we were mindful of references we'd make to and who took credit for killing her and all kinds of stuff regarding her death."
Mannheim Steamroller
Artist: Mannheim Steamroller
Genre(s):
Vocal
Pop: Pop-Rock
New Age
Other
Classical: Neo-Classical
Discography:
Christmas Song
Year: 2007
Tracks: 12
Mannheim Steamroller Christmas Celebration
Year: 2004
Tracks: 18
Romantic Melodies
Year: 2003
Tracks: 12
Halloween
Year: 2003
Tracks: 14
To Russia With Love
Year: 2002
Tracks: 14
Christmas Extraordinaire
Year: 2001
Tracks: 12
Fresh Aire VIII - Infinity
Year: 2000
Tracks: 1
25 Years Celebration Of Mannheim Steamroller Cd2
Year: 1999
Tracks: 13
25 Years Celebration Of Mannheim Steamroller Cd1
Year: 1999
Tracks: 12
Christmas Live
Year: 1996
Tracks: 16
Christmas In The Aire
Year: 1995
Tracks: 12
Fresh Aire 7
Year: 1991
Tracks: 13
Fresh Aire VII - The Mystic
Year: 1990
Tracks: 1
Yelloustone The Music Of Nature
Year: 1989
Tracks: 15
A Fresh Aire Christmas
Year: 1988
Tracks: 12
Saving The Wildlife
Year: 1986
Tracks: 13
Fresh Aire VI Greek Mythology
Year: 1986
Tracks: 1
Fresh Aire 6
Year: 1986
Tracks: 10
Fresh Aire 4
Year: 1986
Tracks: 8
Fresh Aire 5
Year: 1985
Tracks: 7
Fresh Aire V To The Moon
Year: 1983
Tracks: 1
Fresh Aire 3
Year: 1979
Tracks: 9
Fresh Aire 2
Year: 1977
Tracks: 13
Fresh Aire 1
Year: 1975
Tracks: 12
Fresh Aire Iv Winter
Year:
Tracks: 1
Fresh Aire Iii Summer
Year:
Tracks: 1
Fresh Aire Ii Fall
Year:
Tracks: 1
Fresh Aire 8
Year:
Tracks: 12
Fresh Aire 1 Spring
Year:
Tracks: 1
Christmas
Year:
Tracks: 11
The alias of composer Chip Davis, Mannheim Steamroller was among the pioneers of neoclassic electronic music, emerging as one of the drive forces in arrears the New Age phenomenon. Born in Sylvania, Ohio, Davis' father was a heights school music teacher, while his mother was a trombonist with Phil Spitalny's All Girl Orchestra. His nanna was his commencement music teacher, giving the child his initial forte-piano lessons at the age of four-spot; two geezerhood subsequently, Davis composed his commencement slice, a four-part choral written in honor of his heel. He by and by united a boys' choir as well, and spell attention the University of Michigan played bassoon in the school's concert banding. Upon graduating in 1969, Davis was tapped to tour of duty with the Norman Luboff Choir; after five age with the grouping, playacting everything from pop to classic, he returned to Sylvania to teach medicine at the local junior high school, often adapting classical standards to present-day harmonies and rhythms for bookman phthisis.
Jefferson Davis subsequently left education, arranging and conducting an Omaha, Nebraska production of Hair earlier accepting a caper writing publicizing jingles. With colleague Bill Fries, he created the enormously popular C.W. McCall character, later the pattern behind the chart-topping stumble "Convoy; " as the McCall delirium went into heights gear, however, Davis returned to the authoritative adaptations he'd commencement composed piece a teacher, and soon entered the studio to begin transcription what he dubbed "eighteenth c hellenic rock" -- classical music performed on electric bass and synthesizers. He coroneted the resulting record album Fresh Aire, and when no tag would tinct it, he founded his have troupe, American Gramaphone, in 1974, creating a sham band named Mannheim Steamroller to bettor promote the project. Davis initially marketed Refreshing Aire to stereo showrooms, where his state of the art sound proven ideal for demonstrating home stereoscopic photograph equipment; the LP became a smash hit among audiophiles, and a series of popular Refreshed Aire sequels followed in the long time to come.
In 1984, Davis issued Mannheim Steamroller Christmas, which aghast onlookers by selling over 5 trillion copies on the intensity of a Top 40 Adult Contemporary interpretation of "Pack of cards the Halls." It was followed four-spot years by and by by A Fresh Aire Christmas, another unqualified strike. The environment informed 1986's Delivery the Wildlife, the soundtrack to a PBS limited, and was followed terzetto age later by Yellowstone: The Music of Nature, which brocaded over half a billion dollars for the National Parks Service. Although in the early 1990s Davis began recording under his have name for the number 1 time, he too well-kept the Mannheim Steamroller guise for a series of seasonal worker recordings, among them 1995's Christmas Day in the Aire, 1997's Christmas Live and 1998's Christmastide Angel: A Family Story. 1999's two-disc 25 Years famed Mannheim Steamroller's silver day of remembrance. Continuing with their Sweet Aire series, volume ashcan School was released in mid-2000. The albums Romantic Melodies and American Spirit came in 2003.
Subscribe to:
Posts (Atom)